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US President Donald Trump is expected to unveil the new tariffs - taxes on imports - on what he has called "Liberation Day".
Wall Street opened lower on Wednesday, as did the S&P, Dow Jones and Nasdaq, as markets braced for Trump's tariff announcement, which is expected to be released at 4 p.m. (Washington time) on Wednesday.
The S&P 500 was down 0.3% in morning trading, while the Dow fell 140 points, or 0.3%, and the Nasdaq fell 0.2%. Tesla, which has a large influence on Wall Street because of its size, was down again, falling 2.2% to extend its 2025 loss year to date to 35%.
However, strategists say there is an advantage to announcing tariffs - it will end uncertainty.
Asia
Asian stocks showed mixed performance during Wednesday's trading session.
The CSI 300 fell about 0.1 percent, with the MSCI China index down slightly at the closing bell. The Shenzhen Component Index and the S&P China 500 Index both gained about 0.1 percent.
The SSE Composite Index, which represents all shares traded on the Shanghai Stock Exchange, rose 0.1 percent, with Hong Kong's Hang Seng index slightly lower.
Japan's TOPIX closed down 0.4 percent on Wednesday, while the Nikkei 225 - which includes 225 of the largest publicly traded companies on the Tokyo Stock Exchange - gained 0.3 percent.
South Korea's KOSPI index fell 0.6 percent on Wednesday.
Europe
Europe's major indices are all down in early trade.
The EURO STOXX 50 and STOXX EUROPE 600 indices fell 0.9 percent and 1.0 percent, respectively, while the MSCI Europe—which measures the performance of large- and mid-cap stocks in 15 developed European markets—fell 0.1 percent.
Meanwhile, the UK's FTSE 100 and FTSE 250 are both down around 0.5 percent.
Elsewhere, Australia's S&P/ASX 200 index closed down 0.1 percent, while the FTSE/JSE Africa All-Share Index—featuring all companies listed on the Johannesburg Stock Exchange—is down 0.3 percent.
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